Ataxia telangiectasia henkow

Ataxia telangiectasia - Socialstyrelse

Ataxia telangiectasia in the British Isles: the clinical and laboratory features of 70 affected individuals. Q J Med. 1992 Feb; 82 (298):169-179. Wright J, Teraoka S, Onengut S, Tolun A, Gatti RA, Ochs HD, Concannon P. A high frequency of distinct ATM gene mutations in ataxia-telangiectasia. Am J. Variant Ataxia-Telangiectasia (Atypical) Ying and Decoteau (1981) described a family in which a brother and sister may have had an allelic (and milder) form of AT. The proband, a 58-year-old male of Saskatchewan Mennonite origin, had spinocerebellar degeneration associated with choreiform movements beginning at about age 10 years Ataxia telangiectasia henkow. Ataxia-telangiectasia (AT or A-T), also referred to as ataxia-telangiectasia syndrome or Louis-Bar syndrome, is a rare, neurodegenerative, autosomal recessive. Ataxia Telangiectasia Ataxia telangiektasia Svensk definition. Ataxi-telangiektasisyndromet kännetecknas av koreoatetos (danssjuka; ofrivilliga, rytmiska La ataxia telangiectasia (AT) es una enfermedad hereditaria poco frecuente. Afecta el sistema nervioso, el sistema inmunológico y otros sistemas del cuerpo. Los síntomas se presentan en niños pequeños, generalmente antes de los cinco años. Estos incluyen: Ataxia: dificultad para coordinar los movimientos ; Problemas con el equilibri

Ataxia‐telangiectasia: A review of clinical features and

Beyond typical ataxia telangiectasia: how to identify the

Ataxia-telangiectasia is a rare, childhood neurological disorder that causes degeneration in the part of the brain that controls motor movements and speech. The first signs of the disease are unsteady walking and slurred speech, usually occurring during the first five years of life Ataxia Telangiectasia Ataxia telangiektasia Svensk definition. Ataxi-telangiektasisyndromet kännetecknas av koreoatetos (danssjuka; ofrivilliga, rytmiska, återkommande rörelser) som börjar i barndomen, fortskridande cerebellär ataxi, telangiektasi i bindhinnor oc h hud, långsam mental försämring och degenerering av lillhjärnan Herencia. La Ataxia Telangiectasia se hereda como un trastorno autosómico recesivo. El gen responsable de la enfermedad ha sido identificado y se sabe que se encuentra en el cromosoma 11, concretamente en a posición 11q22-23. Éste gen controla la producción de una enzima del tipo -fosfatidilinositol- 3-cinasa, involucrada en respuestas celulares y control de ciclo

Ataxia telangiectasia is an autosomal recessive DNA repair disorder characterised by complex neurological symptoms, with an elevated risk of malignancy, immunodeficiency and other systemic complications. Patients with variant ataxia telangiectasia—with some preserved ataxia telangiectasia-mutated (ATM) kinase activity—have a milder and often atypical phenotype, which can lead to long. Ataxia Telangiectasia is the term which is derived from two clinical presentations: Ataxia- body coordination disorder during walking; Telangiectasia- enlargement of the blood vessels, which is visible through the skin

Ataxia telangiectasia: a review - PubMe

  1. Ataxia telangiectasia (AT) is an autosomal-recessive disorder characterized by a mutation in the ataxia telangiectasia (ATM) gene, which acts as a sensor of double-stranded DNA breakage and activates numerous damage repair pathways, including cell-cycle checkpoint control, p53 activation, and DNA repair. 33,34 Mutations in ATM lead to accelerated telomere loss and premature aging. 35 In the.
  2. Ataxia-telangiectasia resists precise classification among the known entities of heredocerebellar ataxia. It is believed, however, that it may be properly viewed as a fifth entity in the group of phakomatoses, which presently is comprised of Von Recklinghausen's neurofibromatosis, tuberous sclerosis, Von Hippel-Lindau's disease and Sturge-Weber syndrome
  3. Ataxia telangiectasia. Ataxia telangiectasia (AT) tillhör gruppen recessivt ärftliga ataxier. Sjukdomen kallas också Louis-Bars sjukdom och kännetecknas bland annat av en fortskridande förlust av koordinationen av muskelrörelser (ataxi) och vidgade blodkärl i huden
  4. Ataxia-telangiectasia is caused by changes in a gene known as ATM. Genes carry information telling cells within the body how to function. The ATM gene is needed for cells to repair damaged genetic material (DNA). Most people without ataxia-telangiectasia carry two working copies of the ATM gene in their cells
  5. Ataxia Telangiectasia is inherited in autosomal recessive manner, which means that two healthy parents, both carriers of one ATM mutation, have at each pregnancy a 25% risk of giving birth to an affected child. As is the case other autosomal recessive diseases, consanguinity is a risk factor
  6. Ataxia-telangiectasia (A-T) is an autosomal recessive, complex, multisystem disorder characterized by progressive neurologic impairment, cerebellar ataxia, variable immunodeficiency with susceptibility to sinopulmonary infections, impaired organ maturation, x-ray hypersensitivity, ocular and cutaneous telangiectasia (see image below), and a p..
  7. Ataxia telangiectasia (AT) is a rare autosomal-recessive disorder caused by mutations in the AT-mutated ( ATM ) gene (chromosome 11q 22-23) with absent or aberrant ATM protein kinase.1 It is usually characterized by childhood-onset cerebellar ataxia, oculocutaneous telangiectasia, oculomotor apraxia, immunodeficiency, increased malignancy risk, and early mortality (classical AT).1 Recently it.

The ATM gene and ataxia telangiectasia - PubMe

  1. Abstract Background. Ataxia—telangiectasia is an autosomal recessive syndrome in which cancers develop in affected homozygotes at a rate approximately 100 times higher than in unaffected age.
  2. This is a lecture about the genetic disease ataxia-telangiectasia for trainees and medical professionals. Lecture by Philip M. Boone, MD, PhD. Sources: http:..
  3. Ataxia-telangiectasia (A-T) is a rare neurodegenerative, inherited disease causing severe morbidity. Oculocutaneous telangiectasias are almost constant findings among the affected cases as telangiectasia is considered the main clinical finding for diagnosis. Vascular abnormalities in organs have been reported infrequently but bladder wall telangiectasias are extremely rare
  4. Ataxia-telangiectasia (A-T) is a rare autosomal recessive genetic disorder characterized by progressive neurodegeneration, a high risk of cancer and immunodeficiency. These patients are also hypersensitive to radiotherapy. The gene product defective in this syndrome, ATM.

Ataxia telangiectasia: a review Orphanet Journal of Rare

Ataxia-telangiectasia definition is - an inherited systemic disorder marked especially by progressive pathological changes in the nervous system resulting in loss of motor coordination and by increased susceptibility to cancer especially of lymphoid tissue. How to use ataxia-telangiectasia in a sentence What is Ataxia-telangiectasia?Ataxia-telangiectasia (A-T) is a hereditary condition characterized by progressive neurologic problems that lead to difficulty walking and an increased risk of developing various types of cancer. Signs of A-T often develop in childhood. Children with A-T may begin staggering and appear unsteady (called ataxia) shortly after learning to walk The Veldink Family Talks About Ataxia-Telangiectasia - Duration: 10:42. Andy Phelps 3,900 views. 10:42. DNA damage checkpoint and p53 - Duration: 6:55. Animated biology With arpan 17,452 views

Ataxia telangiectasia Radiology Reference Article

Ataxia-Telangiectasia is an autosomal recessive disease that is characterized by impaired balance or coordination (ataxia) and the presence of dilated superficial blood vessel structures calledtelangiectasias. The disease is caused by mutations in the ATM gene, which impairs non-homologous end-joining (NHEJ), a mechanism used to fix double-stranded DNA breaks Ataxia-telangiectasia (A-T) is a rare, inherited disease. It affects the nervous system, immune system, and other body systems. Symptoms appear in young children, usually before age 5. They include Ataxia - trouble coordinating movements Poor balance.. Ataxia involves a lack of muscle coordination and control. There are many different types, including Friedreich's ataxia, ataxia telangiectasia, spinocerebellar ataxia, and more. Learn more about.

Ataxia-telangiectasia (A-T) is a rare hereditary disorder characterized by progressive cerebellar ataxia, conjunctival telangiectasias, recurrent sinopulmonary infections, radiosensitivity, and a predisposition to malignancy. It is the most common cause of progressive cerebellar ataxia in childhood Ataxia telangiectasia is a genetic condition that manifests in early childhood. It causes cerebral ataxia (problems with balance and coordination), immune system abnormalities, and a predisposition to cancer.The photo depicts ocular telangiectasia, which is a reddening of the whites of the eyes caused by dilated blood vessels. Breaks in chromosomes are also a feature of the condition

Ataxia-telangiectasia is a rare multisystem disorder that carries an autosomal recessive inheritance, sometimes classified as a phakomatosis.It is characterised by multiple telangiectasias, cerebellar ataxia, pulmonary infections, and immunodeficiency. On brain imaging, it usually demonstrates vermian atrophy, compensatory enlargement of the fourth ventricle, cerebral infarcts and cerebral. La Ataxia-Telangiectasia es una enfermedad poco reportada en nuestro país. En base a proyecciones de Estados Unidos,la prevalencia promedio seria del 0,002% (688 casos)del total de la población peruana (20), cifra que no puede ser comprobada por la escasez de trabajos o presentación de casos clínicos Ataxia-telangiectasia (AT; OMIM#208900) is a rare genetic disease caused by mutations in the AT-mutated (ATM) gene encoding PI3kinase, which controls the cell cycle and DNA repair. 1 Patients with classic AT present with early-onset progressive cerebellar ataxia, oculocutaneous telangiectasias, immunodeficiency, late-onset peripheral neuropathy, and higher incidence of infections and tumors Classic ataxia-telangiectasia (AT) is a rare autosomal recessive disorder characterized by progressive cerebellar dysfunction leading to unsteady gait in early childhood, oculomotor apraxia, and ocular and cutaneous telangiectasias.1,2 Other neurologic features such as movement disorders, dysarthria, and peripheral neuropathy are usually present, and non-neurologic features include.

Ataxia-telangiectasia. This rare, progressive childhood disease causes degeneration in the brain and other body systems. The disease also causes immune system breakdown (immunodeficiency disease), which increases susceptibility to other diseases, including infections and tumors Diagnosis. If you have ataxia, your doctor will look for a treatable cause. Besides conducting a physical exam and a neurological exam, including checking your memory and concentration, vision, hearing, balance, coordination, and reflexes, your doctor might request laboratory tests, including Ataxia-telangiectasia mutated (ATM) kinase is a member of the phosphatidylinositol 3-kinase (PI3K)-related kinase (PIKK) family of atypical serine/threonine protein kinases (also comprising ATR, DNAPKcs, mammalian target of rapamycin (mTOR), SMG1, and the nonenzymatic TRRAP) 12 and plays a central role in the DDR by regulating the detection and repair of DNA DSBs. 13, 14 ATM derives its name. Abstract. Ataxia Telangiectasia (AT; OMIM #208900) is a multisystemic autosomal recessive disorder characterized by progressive cerebellar ataxia, oculocutaneous telangiectasias, immunodeficiency, recurrent sinopulmonary infections, growth retardation, endocrine abnormalities, hypogonadism and cancer proneness, with laboratory evidence of increased alpha- fetoprotein levels, chromosomal. Savitsky K, Bar-Shira A, Gilad S, et al. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 1995; 268:1749. Ambrose M, Gatti RA. Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions. Blood 2013; 121:4036

With ataxia telangiectasia, ataxia refers to poor coordination and telangiectasia refers to dilated blood vessels, which are the two key symptoms of this disease. Ataxia telangiectasia develops when a genetic mutation causes the lack of a protein called ataxia telangiectasia mutated serine-threonine kinase, or just ATM for short, which normally fixes up damaged DNA Ataxia telangiektasia Nyhetsbrev 252 På Ågrenska arrangeras veckovistelser där familjer med barn med funktionshinder bor och utbyter erfarenheter. Under en och samma vecka träffas ett antal familjer med barn som har samma diagnos, i det här fallet Ataxia telangiektasia Ataxia telangiectasia (AT) is a multisystemic complex syndrome that is typically transmitted in an autosomal recessive mode of inheritance and it is included among chromosomal breakage syndromes Ataxia-telangiectasia may occur in any race or sex. Reported rates of incidence range from 1 in 40,000 to 1 in 100,000 births. The incidence of ataxia-telangiectasia is significantly higher when parents are consanguineous, for example in the Bedouin population

Ataxia-telangiectasia: identification and detection of

  1. La ataxia-telangiectasia clásica se llega a caracterizar por una especie de progresiva ataxia cerebelosa entre las edades de 1 y 4 años, apraxia oculomotora, la dificultad en el habla, la coreoatetosis, una telangiectasia conjuntiva, diversas infecciones frecuentes, la inmunodeficiencia y también un mayor riesgo de padecer de cáncer, en especial la leucemia y el linfoma
  2. Ataxia-Telangiectasia (A-T) is an inherited disease that affects several body systems, including the immune system. People with A-T have an unsteady, wobbly gait (ataxia) that gets worse as they get older; dilated, corkscrew-shaped blood vessels (telangiectasia) on the whites of the eyes and on sun-exposed areas of skin; immunodeficiency involving both humoral (B-lymphocytes
  3. Ataxia-telangiectasia is a rare inherited disorder that affects the nervous system, immune system, and other body systems. Ataxia-telangiectasia is a rare, recessive genetic disorder of childhood that occurs in between 1 out of 40,000 and 1 out of 100,000 persons worldwide. The ailment is progressive


La ataxia-telangiectasia (A-T) es una enfermedad genética autosómica recesiva poco frecuente (1/100.000 en la población) causada por mutaciones del gen ATM localizado en el cromosoma 11 (1,2). La proteína ATM es esencial para la señalización y reparación normal de las rotura Ataxia-Telangiectasia: Reporte de caso Ataxia-Telangiectasia: Case report Edwin Lazo Rivera1,2,a, Luis Fernando Pastor Vizcarra1,3,b. RESUMEN Presentamos el caso clínico de un niño de 9 años procedente de la región Cusco, con deterioro progresivo del estad Ataxia Telangiectasia by the Florida Medical Association. Questions and Answers: Ataxia Telangiectasia by National Institutes of Health. Virginia Mason Research Center: Ataxia-Telangiectasia Mutation Database. ATbase - a registry of patients with ataxia-telangiectasia by Karolinska Insitutet, Stockholm, Sweden Ataxia-telangiectasia (A-T) is caused by inactivating mutations of the ATM gene (11q22.3). This gene is expressed ubiquitously and encodes a protein kinase playing a key role in the control of double-strand-break (DSB) DNA repair, notably in the Purkinje cells of the cerebellum and in cerebral, cutaneous and conjunctival endothelial cells

Ataxia telangiectasia henkow — den europeiska databasen

Ataxia telangiectasia is a rare genetic disease that causes multiple symptoms related to poor co-ordination, abnormal blood vessels and a compromised immune system. There is no treatment for ataxia telangiectasia and management focuses on monitoring and treating the specific risks posed by the condition, such as lung infections. In The C Word, Emily Lawson has inherited more than two copies of. Ataxia-telangiectasia is chiefly characterized by progressive cerebellar ataxia, conjunctival and cutaneous telangiectasias, severe immune deficiencies, recurrent sinopulmonary infections, and a markedly increased risk of malignancy

Ataxia-Telangiectasia or Louis Bar Syndrome is usually diagnosed based on the characteristic features ataxia, telangiectasia, abnormal ocular movements and impairment of speech. This diagnosis can be confirmed by laboratory screening. With observation of all the clinical signs and symptoms the diagnosis can be made relatively easily Other articles where Ataxia-telangiectasia is discussed: nervous system disease: Neurocutaneous syndromes: Ataxia-telangiectasia (Louis-Bar syndrome) results in cerebellar incoordination and choreic movements, overgrowth of blood vessels on the conjunctiva (eye membranes), and disorders of the immune system

The serum-α-fetoprotein concentrations of twenty patients with ataxia-telangiectasia, one hundred and forty-nine normal children and adults, fifteen siblings and eleven parents of patients with ataxia-telangiectasia, and fifty-four patients with other immunodeficiency states were measured using a sensitive double-antibody radioimmunoassay. All serum-α-fetoprotein concentrations in patients. Test description. This test analyzes the ATM gene, which is associated with ataxia-telangiectasia (A-T). Individuals with pathogenic variants in both copies of the ATM gene can develop A-T, a condition characterized by childhood-onset progressive cerebellar ataxia, oculomotor apraxia, choreoathetosis, telangiectasias of the conjunctivae, immunodeficiency, and increased risk for malignancy. Ataxia telangiectasia (AT) is a rare, progressive, neurodegenerative childhood disease that affects the nervous system and other body systems. The hallmarks of AT are ataxia (lack of muscle control) and other movement disorders, and telangiectasias (tiny, red spider veins), which appear in the corners of the eyes or on the surface of the ears and cheeks after the onset of ataxia Symptomatic: Ataxia telangiectasia is a genetic condition with no cure. As such, therapy is directed at treating consequences of this disease. For example, it is best to avoid excess radiation (excess x-rays, ct scans) be wary of any signs of infection (due to immune compromise) and be vigilant about signs of malignancy (weight loss, night sweats, etc.) Ataxia telangiectasia.Hirsutism on the lower legs and ecchymoses secondary to ataxia and numerous falls.. Ataxia telangiectasia is a progressive neurodegenerative genetic disease characterized by cerebellar ataxia (incoordination and lack of balance), ocular telangiectasia (red eyes due to widening of small blood vessels in the conjunctiva), immune defects, and a predisposition to malignancy

Fact Sheets Whom does NAF serve? An estimated 150,000 Americans are affected by heredity or sporadic ataxia. Ataxia can strike anyone at any time regardless of age, gender, or race. Ataxia is a group of progressive neurological diseases which affects coordination and speech. NAF membership includes the following: Persons with heredity or sporadic ataxia, their Read More.. Ataxia telangiectasia is a progressive cerebellar degenerative disease with telangiectasia, immunodeficiency, premature aging , cancer risk, radiosensitivity, and chromosomal instability. Prognosis: Prognosis is poor: median age at death: 17 years; survival rarely exceeds 30 years, though survival is increasing with improved medical care

Ataxia telangiectasia: MedlinePlus en españo

  1. a·tax·i·a tel·an·gi·ec·ta·si·a , ataxia-telangiectasia [MIM*208900] an autosomal recessive multisystem disorder consisting of ataxia, ocular apraxia, hypotonia, proprioceptive sensory loss, areflexia, and choreoathetosis; onset typically in early childhood; systemic features include increased susceptibility to malignancies, conjunctival and.
  2. Ataxia Telangiectasia (AT) is a rare worldwide disease inherited as autosomal recessive with a poor prognosis in its classical form. It is characterized by neurological impairment (progressive cerebellar ataxia, axonal peripheral neuropathy, oculomotor apraxia, and movement disorders such as dystonia, choreoathetosis, myoclonus, tremor, Parkinsonism), telangiectasias, recurrent sino pulmonary.
  3. Little Steps for Linkoln and Ataxia Telangiectasia, Devon (ort i Kanada). 784 gillar. We have created this Foundation to help fight this disease that is effecting our son and other families. This is..
  4. gly harmless, their unique appearance together with ataxia is what led to na

Definition of the disease: Ataxia telangiectasia (A-T) is an autosomal recessive disorder primarily characterized by cerebellar degeneration, telangiectasia, immunodeficiency, cancer. Ataxia telangiectasia (AT): Also known as Louis-Bar Syndrome, AT is an inherited condition. It typically develops in babies or young children. A common symptom of this type of ataxia is the appearance of enlarged (dilated) blood vessels known as telangiectasias in the eyes and on the skin of the face Ataxia telangiectasia (A-T) results from inactivation of the ATM protein kinase. DNA-damage signaling is a prime function of this kinase, although other roles have been ascribed to ATM. Identifying the primary ATM function(s) for tissue homeostasis is key to understanding how these functions contribute to the prevention of A-T-related pathology. In this regard, because A-T is primarily a. Ataxia-telangiectasia is an autosomal-recessive primary immunodeficiency disorder that involves combined humoral and cellular deficiencies. Estimated incidence is 1 in 20,000 to 100,000 births. Ataxia-telangiectasia is caused by mutations in the gene that encodes ataxia-telangiectasia-mutated (ATM) protein

Variant ataxia-telangiectasia presenting as primary-appearing dystonia in Canadian Mennonites. Neurology. 2012 Feb 15. [Epub ahead of print] PubMed PMID: 22345219. PubMedID: 22345219. Gatti RA, Boder E, Vinters HV, Sparkes RS, Norman A, Lange K. Ataxia-telangiectasia: an interdisciplinary approach to pathogenesis Having ataxia telangiectasia also puts the child at a 37 times higher risk for developing cancer. There is a 10% risk of developing leukemia or lymphoma if diagnosed with ataxia telangiectasia Incidence: Ataxia Telangiectasia (A-T) has a frequency of approximately 1 in 40,000 births in the United States.. The carrier rate of A-T, which is an autosomal recessive genetic condition, is approximately 2.8% in the United States.. Natural Histor Ataxia is the term for a group of disorders that affect co-ordination, balance and speech. Find out about the main types, what causes them, and how they're treated

Although the cutaneous aspects of ataxia-telangiectasia (AT) are emphasized in the name, there have been no extensive clinical and histopathological studies of the skin of these patients. The immunologic deficiencies and the minimal thymic activity was first noted by Peterson, Kelly, and Good 56 and confirmed by others. 27,30,65,77 We wish to report the dermatological findings in 22 patients. Ataxia-telangiectasia is a rare childhood disease. It affects the brain and other parts of the body. Ataxia refers to uncoordinated movements, such as walking. Telangiectasias are enlarged blood vessels (capillaries) just below the surface of the skin. Telangiectasias appear as tiny, red, spider-like veins Ataxia - telangiectasia Definition Ataxia-telangiectasia is a rare childhood disease. It affects the brain and other parts of the body. Ataxia refers to uncoordinated movements, such as walking. Telangiectasias are enlarged blood vessels (capillaries) just below the surface of the skin. Telangiectasias appear as tiny, red, spider-like veins

Ataxia telangiectasia definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now Ataxia Telangiectasia At Epidemiology Forecast. DelveInsight's 'Ataxia Telangiectasia (AT) - Epidemiology Forecast to 2030' report delivers an in-depth understanding of the disease, historical and forecasted Ataxia Telangiectasia (AT) epidemiology in the 7MM, i.e., the United States, EU5 (Germany, Spain, Italy, France, and the United Kingdom), and Japan • FRIEDERICK'S ATAXIA• ATAXIA TELANGIECTASIA• ATAXIA WITH ISOLATED VIT.E DEFICIENCY• ABETALIPOPROTEINEMIA• ENZYME DEFICIENCIES (Maple Syrup urinedisease, Urea cycle defects, Sialidosis,Adrenoleucodystrophy,Organic aciduria,Pyruvate dehydogenase def.)AUTOSOMAL RECESSIVE ATAXIAS 53

Ataxia - telangiectasia: MedlinePlus enciclopedia médic

Ataxia Telangiectasia La Ataxia-Telangiectasia es una heredo-ataxia multisistemica heredada de manera autosomia recesiva. Caracterizada por ataxia cerebelar, inmunodeficiencia, radio sensibilidad, telangiectasias oculocutaneas, y con predisposición a enfermedades neoplásicas. Alaysha 3. Ataxia Telangiectasia 4 Ataxia-telangiectasia (AT), or Louis-Bar syndrome, is an autosomal recessive disorder that primarily involves the CNS (particularly the cerebellum), the ocular surface, the skin, and the immune system. Though rare (prevalence is about 1:40,000), AT is thought to be the most common cause of progressive ataxia in early childhood

Ataxia telangiectasia Genetic and Rare Diseases

Ataxia-telangiectasia (AT) is a multisystem disease; immunodeficiency is common and children may initially present with recurrent viral or bacterial sinopulmonary infections secondary to. Ataxia-telangiectasia (A-T) is an autosomal recessive disorder characterized by neurodegeneration, combined immunodeficiency, and oculocutaneous telangiectasia. The hyper-IgM phenotype of A-T, correlating with a class-switch recombination defect, IgG and IgA deficiency, T helper and B cell lymphopenia, immune dysregulation, proinflammatory immune response, autoimmune disease, and a high risk.

Ataxia telangiectasia: A report of two cousins and review

Serine/Threonine Protein Kinase ATR - Pipeline Review, H1 2020 Summary Serine/Threonine Protein Kinase ATR (Ataxia Telangiectasia And Rad3 Related Protein or FRAP Related Protein 1 or ATR or EC pipeline Target constitutes close to 17 molecules. Out of which approximately 16 molecules ar

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